Organotin iv carboxylates as promising potential drug candidates in the field of cancer chemotherapy. High yield of the products can be achieved by the azeotropic reflux of the reactants in boiling toluene using a dean and stark separator. The advantage of the use of sulfur free stabilizers is the good photostability and the lack of odor. Organotiniv complexes of carboxylic acid derivatives. The crystal and molecular structure of nbu2sn2meoc6h4coo2o2. They are however less efficient as heat stabilizers than the sulphurcontaining organotin mercaptides. Amide based organotiniv carboxylates may be one of the better alternate drug against leishmaniasis. The organic group may be an alkyl chain or an aromatic ring. The hemolytic activity of the complexes was lower compared to tritonx 100 positive control, 100% lysis and higher than phosphatebuffered saline negative control, 0% lysis. Six diorganotiniv carboxylates prepared by reacting diorganotiniv dichlorides with the respective silver carboxylate have been tested for antifungal activity against aspergillus.
Antifungal activity of organotin compounds with functionalized carboxylates evaluated by the microdilution bioassay in vitro. We must point out that for all three tested organotin carboxylates mic 100% values were fixed as distinct from mic 50% values for fluconazole. In this context, metal based drugs like organotiniv may play an. Pdf organotiniv carboxylates as promising potential. Organotins are organometallic compounds based on organic derivatives of the. The effects of organotin catalysts on hydrolytic condensation of. The compounds generally exhibit greater fungitoxicity than the diorganotiniv dichlorides and the carboxylic acids from which. Organotin chemistry is part of the wider field of organometallic chemistry. Pdf synthesis, characterization, semiempirical and biological. With tweezers, carefully transfer the filter to a 125ml beaker. The triphenyltiniv product 3 showed interaction with salmon sperm dna and was found to be the most active antimicrobial agent having the lowest hemolytic effects. Recently, interests in organotiniv carboxylates are increasing due to.
Common alkyl chains are butyl or octyl, and a common aromatic ring is phenyl. It is well known that the organotin carboxylates have versatile. Synthesis, characterization, and biological studies of organotiniv. Mass spectroscopic and biological activity investigations. This should include, the wiley titles, and the specific portion of the content you wish to reuse e. The organotin chlorides are very convenient starting materials for the synthesis of the organotin cyanides, azides, isocyanates and isothiocyanates from the appropriate metal salts equations 143146. Davies has updated the contents of his book to reflect the current state of research into organotin chemistry. Newly designed organotiniv carboxylates with peptide. The structures of these complexes are discussed on the basis of ir, multinuclear 1h, c and 119sn nmr. Organotin methyl and butyl toxicity occurrence tin sn is a silver metal atomic number 50 that occurs in the earths crust mainly as cassiterite or tinstone sno2 which is the main source of tin. Us4681907a stabilizers for halogencontaining organic. The first organotin compound was diethyltin diiodide c 2 h 5 2 sni 2, discovered by edward frankland in 1849. Saponification of the stearate sample yielded a tincontaining residue which was insoluble in all the.
Synthesis, characterization, semiempirical and biological. Compositions comprising an organotin mercaptide, organotin sulfide, organotin carboxylate or mixtures thereof and a diester of an ethylenically unsaturated dicarboxylic acid having one carboxyl group on each carbon atom of the ethenylene group are useful for stabilizing halogencontaining organic polymers against the deteriorative effects of heat, light and weathering. Koji nemoto, yoshiaki hirano, keiichi hirata, tsukasa takahashi, hideaki tsuneki, kenichi tominaga, kazuhiko sato. The sulphur free organotin carboxylates, and in particular tin maleates, confer excellent light stability to finished goods intended for outdoor applications. Atrftir spectroscopy detects alterations induced by.
Prepare a standard mixture of the organotin compounds of interest. In most of these systems, a solvent is used to reduce the viscosity to assist application. Among the organotins, organotin carboxylates are important. The structures of these l compounds have been evaluated by various analytical techniques such as elemental analysis, multinuclear nmr 1h, c and 119sn and mass spectrometry. He covers all aspects in detail, such as its synthesis, characterization, structures and applications, while also devoting space to such hot topics as environmental issues. If the inline pdf is not rendering correctly, you can download the pdf file here.
Organotin definition of organotin by the free dictionary. Pdf antifungal activity of organotin compounds with. Lowline edge roughness extreme ultraviolet photoresists. Pdf medicinal inorganic chemistry plays an important role in exploring the properties of metal ions for the designing of new drugs.
Antibiotic resistance is another leading problem because of various types of bacterial strains. Synthesis, structural elucidation, physicochemical characterizations and pharmacological investigations, european journal of medicinal chemistry on deepdyve, the largest online rental service for scholarly research with thousands of academic publications available at your fingertips. The complexes displayed significant antimicrobial activities against bacterial and fungal strains as compared to free ligand. Synthesis spectroscopic characterization and biological activities volume. Department of chemistry, allama iqbal open university islamabad 44000, pakistan. In the final step the remaining chloride anions can be substituated by the desired anion e. The second, completely revised edition of this comprehensive standard reference. Synthesis, characterization and antimicrobial evaluation. Read newly designed organotiniv carboxylates with peptide linkage. Based on spectroscopic evidence ir and nmr, all the triorganotin carboxylates. The field of organotin chemistry has a long history that started since 1849, when frankland isolated a specimen of diethyltin diiodide 1. The organotiniv carboxylates displayed powerful antimicrobial activities against.
Organotin mercapto ethylene carboxylates and method for. Carboxylate definition of carboxylate by the free dictionary. Research article synthesis, characterization, semiempirical and biological activities of organotiniv carboxylates with 4piperidinecarboxylic acid shabbirhussain, 1 saqibali, 2 sairashahzadi, 2 sarojk. Pdf organotiniv carboxylates as promising potential drug. Synthesis, characterization, biological activities.
Thremogravimetric tg studies of a new series of organotiniv carboxylates of the general formula r n snl 4n where r ch 3, c 2 h 5, c 4 h 9, c 6 h 5, c 6 h 11 and c 8 h 17, n 2, 3 and l paramethoxyphenylethanoate anion have been carried out. Organotin carboxylates are generally prepared by the reaction of organotin oxide or hydroxide with carboxylic acids. Organotiniv carboxylates of cyclopropane carboxylic acid. Germatranes, diethyltin, tribenzyltin, spectroscopy, antileishmanial activity. Organotiniv complexes of carboxylic acid derivatives in. Ch3 o snch2ch2ch2 ch33 n n och2ch3 ch3ch2ch2ch23sn n s och 2ch3 ch 3ch 2ch 2ch23sn o n ch 3ch2ch ch sn cooch2 n n cl snch2ch2ch2ch33 cl ch 3ch sn o ch32cho n n ch ch2 sn och 3 n och2ch3 snch2ch2ch2ch33 n s och3 ch 3ch 2ch ch sn. Thanks for helping us catch any problems with articles on deepdyve. An overview is given of the research on organotin carboxylates, including architecture formation, molecular and supramolecular architectural styles, spectra studies and antitumour activities. The convention prohibits the new application of listed antifouling systems and it imposes a requirement that organotin biocides be removed from hulls or overcoated to prevent leaching note. The area grew rapidly in the 1900s, especially after the discovery of the grignard reagents, which are. Complete patent searching database and patent data analytics services. Method 5504, issue 2 dated 15 august 1994 page 3 of 6 niosh manual of analytical methods nmam, fourth edition, 81594 5.
Organotin chemistry wiley online books wiley online library. Organotiniv derivatives of amidebased carboxylates. In 1852, lowich reported on the reaction of alkyl halides with a tinsodium alloy giving alkyltin compounds 2. Organotiniv carboxylates as promising potential drug candidates in the field of cancer chemotherapy.
Sharma, 3 kushalqanungo, 3 andmuhammadshahid 4 department of chemistry, gc university, faisalabad, pakistan. Tin in the form of a metal and its alloys were known to the ancient people and have greatly affected the course of human history. Organotiniv complexes with ons donor schiff base ligand. Spectroscopic and xray structural characterization of new organotin carboxylates and their in vitro antifungal activities. Synthesis, chemical characterization and biological.
Pdf organotin iv carboxylates with the general formulae r2sncll r me. Synthesis and spectroscopic properties of diorganotiniv complexes with oanisic acid. Organotin carboxylates are commonly prepared by the reaction of organotin. The complexes exhibited comparatively higher hemolytic activity as compared to free ligand. Organotin carboxylates are important catalysts in aliphatic urethane synthesis. The organotiniv complexes displayed lower cytotoxic effects 12. Organotin chemistry, 2nd, completely revised and updated. Pdf organotin carboxylate catalyst in urethane formation.
Organotin compounds or stannanes are chemical compounds based on tin with hydrocarbon substituents. In contrast to sulfurcontaining tin compounds, tin carboxylates have to be used with antioxidants. Synthesis and antifungal activity of some organotiniv. Synthesis, characterization, semiempirical and biological activities. Thus by using organotin carboxylate for clinical medicine, cost reduction. Additionally, photosensitivity was found to be linearly related to free radical stability of the hydrocarbon group. His work has covered the interconnecting themes of organic peroxides, organometallic chemistry, free radical chemistry, and the organic and organometallic applications of esr spectroscopy, and his published work includes a book on organic peroxides 1961, and the first edition of organotin chemistry 1997. Horowitz and metzger method has been used to calculate thermokinetic parameters.
554 95 1640 872 108 1643 147 1396 233 676 43 754 1652 281 495 398 723 1287 890 567 1388 1470 213 1351 1437 413 1147 296 987 52 244 687 1347 126 895 1296 705 548 541 225 1187 672 1094 1391 1485 76 702 321 528